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DSIP
99%+ Purity

DSIP Peptide

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide neuropeptide first discovered in 1974, composed of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu). Research demonstrates DSIP significantly enhances sleep quality, particularly slow-wave deep sleep, while reducing sleep latency without sedative effects. Studies show DSIP modulates the hypothalamic-pituitary-adrenal axis, reducing cortisol and stress responses. Clinical trials demonstrate remarkable efficacy in treating withdrawal symptoms, with 97% of opiate-dependent and 87% of alcohol-dependent patients experiencing symptom relief. DSIP exhibits analgesic properties for chronic pain conditions, neuroprotective effects through antioxidant mechanisms, and geroprotective actions including 2.6-fold reduction in spontaneous tumor incidence in long-term studies. For Research Use Only. Not intended for human or veterinary use.

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Certificate of Analysis

Third Party TestedISO/IEC 17025 Accredited
ISO 170253rd Party
99.007%
Purity
Passed full QC panel
TestedFeb 20, 2026
Full QC Panel
Purity (HPLC)99.007%
ISO/IEC 17025 Accredited

Compound Information

Structured specifications and handling data

Molecular profile

Technical specifications

Type:Endogenous Nonapeptide
CAS Number:62568-57-4
Molecular Weight:848.8 g/mol
Amino Acids:9
Sequence:Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Formula:C35H48N10O15
PubChem Database
Storage requirements

Stability and handling

Room Temperature
Lyophilized
Light Sensitive
Storage TemperatureStore in a cool, dry place away from light; refrigerate at 2–8°C (36–46°F)
ReconstitutionReconstitute with sterile water or bacteriostatic water if applicable
StabilityStable when stored properly; avoid repeated freeze-thaw cycles
Chemical structure

Molecular model

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DSIP research overview

DSIP was discovered in the late 1970s when researchers isolated it from rabbit brain tissue and noticed it was associated with increased delta wave activity on EEG recordings. Delta waves are the large, slow brainwaves associated with deep sleep stages. Since then, studies have examined its effects on sleep architecture, including slow-wave sleep duration, sleep spindle activity, and REM sleep patterns in animal models.

Beyond sleep, DSIP research has expanded into circadian biology and stress physiology. Animal behavioral studies have looked at how it relates to daily activity rhythms and stress-induced responses. Laboratory work has explored its interactions with several neurotransmitter systems, including GABA (the brain's main inhibitory system), serotonin, and dopamine, in brain tissue preparations.

Stress hormone research has examined DSIP's association with corticosterone and ACTH levels in experimental stress models. Researchers have also created synthetic variants of DSIP to study which parts of the nine-amino-acid sequence are essential for its observed effects. With over 500 published papers, DSIP remains an active area of research in sleep physiology and neuroendocrine regulation. For Research Use Only. Not intended for human or veterinary use.

EEG Studies

Research has investigated effects on delta wave and sleep spindle activity in electroencephalography experiments.

Circadian Research

Animal studies have explored associations with circadian locomotor patterns and neuroendocrine timing systems.

Structure-Activity

Research has examined sequence specificity using peptide analogs and modifications in electrophysiological assays.

Sleep Parameters

Studies have investigated effects on sleep continuity and architecture measurements in experimental protocols.

Research evidence

Published studies and concise summaries for research review.

Research Paper
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The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide
Schoenenberger GA, et al.
View Paper
Research Paper
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AI-generated summary of this research paper below.

This study reports the amino-acid sequence of DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), its chemical synthesis, and comparative testing against metabolic fragments and analogs. In intraventricular rabbit studies, synthetic DSIP selectively enhanced delta and spindle EEG activity, while related peptides did not. The authors conclude that DSIP activity is highly sequence-specific and dependent on the correct Asp isomer.
Research overview
Total Papers
529+
Year Range
1977+
Research status
Active
Peer-reviewed studies available
Research FAQ

Frequently asked questions

Concise answers about laboratory context, handling, and documentation for this compound.

Laboratory compliance notice

All compounds sold by Validated Peptides are intended for in-vitro laboratory research only.

These materials are not approved by the FDA for human or animal use and are not intended for diagnostic, therapeutic, or clinical applications.

Purchasers are responsible for compliant handling, storage, and use within an appropriate laboratory environment.

Research Use Only
Not for Human Use
21+ Required