TB-500 Peptide
TB-500 is a 43 amino acid synthetic version of thymosin beta-4, a protein found naturally in nearly every mammalian cell. Its primary job in the body is binding actin, one of the main building blocks of a cell's internal skeleton. Researchers study TB-500 to understand how that actin-binding activity influences cell movement, blood vessel formation, and inflammatory signaling in cell culture and animal models. For Research Use Only. Not intended for human or veterinary use.
Certificate of Analysis
Compound Information
Structured specifications and handling data
Technical specifications
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-SerC212H350N56O78SStability and handling
Molecular model
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TB-500 research overview
TB-500 is a synthetic copy of thymosin beta-4, a small protein your cells naturally produce in large quantities. Thymosin beta-4 binds to actin, which is one of the main structural proteins inside cells. By grabbing onto individual actin molecules, it helps control whether actin assembles into long filaments or stays as single units. That balance matters because actin filaments are what allow cells to change shape, move, and divide.
In laboratory experiments, researchers have watched TB-500 influence how fibroblasts, skin cells, and blood vessel cells reorganize and migrate. It has also been associated with increased levels of VEGF (vascular endothelial growth factor), a signaling protein that tells the body to build new blood vessels. This connection to blood vessel formation is one of the main reasons researchers find it interesting.
Beyond cell movement and blood vessel research, scientists have also explored how TB-500 interacts with inflammatory signaling molecules like interleukin-6 and TNF-alpha in immune cell experiments. There is also ongoing research into how it affects the way cells grip and attach to surfaces around them, a process that involves proteins called integrins and focal adhesion kinase. For Research Use Only. Not intended for human or veterinary use.
Research evidence
Published studies and concise summaries for research review.
AI-generated summary of this research paper below.
Frequently asked questions
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Laboratory compliance notice
All compounds sold by Validated Peptides are intended for in-vitro laboratory research only.
These materials are not approved by the FDA for human or animal use and are not intended for diagnostic, therapeutic, or clinical applications.
Purchasers are responsible for compliant handling, storage, and use within an appropriate laboratory environment.