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Semax is a seven-amino-acid synthetic peptide based on a fragment of ACTH (adrenocorticotropic hormone), a natural signaling molecule in the brain. Researchers study it primarily for its effects on BDNF (brain-derived neurotrophic factor), a protein that supports the growth and survival of nerve cells. Laboratory work has explored its interactions with monoamine neurotransmitter systems like dopamine and serotonin, and animal studies have examined its association with markers of synaptic plasticity and oxidative stress. For Research Use Only. Not intended for human or veterinary use.
Semax is built from a fragment of ACTH, a hormone the pituitary gland produces that is involved in stress response signaling. The fragment Semax is based on does not appear to carry the hormonal activity of full-length ACTH, but researchers found it has distinct effects on neurotrophic factor expression. Its main area of study involves BDNF (brain-derived neurotrophic factor), a protein that helps nerve cells grow, mature, and maintain their connections.
In neuronal cell cultures, researchers have measured Semax's effects on BDNF mRNA levels, which is a way to track whether cells are ramping up production of this neurotrophic protein. Animal studies have gone further, looking at markers of synaptic plasticity, which is the ability of connections between neurons to strengthen or weaken over time. Research has also explored how Semax interacts with monoamine systems, specifically the dopamine and serotonin pathways, in brain tissue preparations.
Additional research areas include oxidative stress and antioxidant enzyme activity in neuronal models. Animal behavioral studies have examined associations with learning and memory performance in standard rodent test paradigms. With over 200 published papers, Semax is one of the more established research peptides in the neurotrophic signaling field. For Research Use Only. Not intended for human or veterinary use.
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All compounds sold by Validated Peptides are intended for in-vitro laboratory research only.
These materials are not approved by the FDA for human or animal use and are not intended for diagnostic, therapeutic, or clinical applications.
Purchasers are responsible for compliant handling, storage, and use within an appropriate laboratory environment.