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GLP-1S is a 31 amino acid synthetic version of glucagon-like peptide-1, one of the gut hormones that helps coordinate insulin release after eating. It has been chemically modified in two ways: a substitution that protects it from being broken down by an enzyme called DPP-4, and a fatty acid attachment that lets it hitch a ride on albumin in the bloodstream, keeping it active much longer than the natural version. Researchers study it to understand GLP-1 receptor signaling, insulin dynamics, and gastric emptying in laboratory models. For Research Use Only. Not intended for human or veterinary use.
GLP-1S is modeled after GLP-1, a hormone the gut releases when food arrives. Normally, natural GLP-1 gets broken down within minutes by an enzyme called DPP-4. GLP-1S has been engineered with a small amino acid swap at one position that blocks DPP-4 from cutting it apart, plus a fatty acid chain that lets it bind reversibly to albumin (a common blood protein). Together, these modifications keep it circulating much longer in experimental models.
When GLP-1S activates the GLP-1 receptor on a cell, it triggers production of cyclic AMP, an internal messenger that kicks off a cascade of downstream signals. In isolated pancreatic cell preparations, researchers have studied how this receptor activation influences insulin release in the presence of glucose. Animal models have been used to study its effects on gastric emptying, which is the rate at which the stomach passes food along to the intestine.
GLP-1S is one of the most heavily published peptides in incretin research, with thousands of papers exploring its pharmacology. Researchers have also used it to study glucose tolerance, insulin sensitivity, and how single-receptor GLP-1 activation compares to the dual and triple-receptor approaches seen in peptides like GLP-2T and GLP-3R. For Research Use Only. Not intended for human or veterinary use.
Structured specifications and handling data
Technical specifications
H-Aib-EGTFTSDVSSYLEGQAAK(γGlu-(AEEA)₂-C18 diacid)EFIAWLVRGRG-OH (31-amino-acid linear peptide based on GLP-1(7-37) with Aib at position 2, Arg at position 28, and Lys20 acylation; full one-letter sequence with modifications refer to structural diagrams in primary literature)C187H291N45O59Stability and handling
Molecular model
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Laboratory compliance notice
All compounds sold by Validated Peptides are intended for in-vitro laboratory research only.
These materials are not approved by the FDA for human or animal use and are not intended for diagnostic, therapeutic, or clinical applications.
Purchasers are responsible for compliant handling, storage, and use within an appropriate laboratory environment.